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Long-term survival of monkey with transplanted pig kidney offers hope in alternative organ search: Scientists_我的网站

A |     Harvard-affiliated scientists say they have been able to keep a monkey alive for two years with a genetically engineered pig kidney. Although preliminary, transplant experts say this research is an important milestone in the search for an alternative source of organs.Scientists are hopeful that one day, genetically modified organs grown in pigs may be able to significantly extend the life of people with end-stage organ failure.In recent months, other high-profile research teams at New York University and the University of Alabama at Birmingham announced successful transplants of genetically modified pig-kidneys into brain dead human donors. But those experiments ended after a few weeks."Duration of survival has been an Achilles heel of genetically modified pig organs to date due to a combination of rejection and opportunistic infections," said Dr. Peter Chin-Hong, director of the transplant infectious disease program at University of California, San Francisco.This new research, published in Nature, represents the longest period of time that scientists have been able to keep a non-human primate research animal alive."This proof-of-concept study provides real hope that transplantation of porcine [pig] donor kidneys into humans is very much on the horizon," Chin-Hong said.Still, experts cautioned that this new research was preliminary, and the idea of pig-grown organs is likely several years away from becoming a reality."If ultimately proved successful in human organ recipients - which is still years away at this point - this could be one of the key advances needed to make xenotransplantation a reality in clinical practice," said Dr. Josh Levitsky, president of the American Society of Transplantation.The new research was led by eGenesis, a company co-founded by Harvard geneticist George Church. In a press release, scientists at eGenesis said the new research will help lay the groundwork for formal clinical trials.In prepared remarks, eGenesis CEO Michael Curtis, PhD, said the company is focused on "improving long-term survival for transplant recipients from months to years."Eventually, the hope is that transplant doctors will be able to use genetically modified pig organs instead of solely relying on deceased human organ donors."Among all solid organs transplanted, kidneys are most sought after, expected to increase in demand further, and there is a significant shortfall of organs leading to premature deaths," Chin-Hong said.Every day, 17 people die waiting on the organ transplant list, according to the Health Resources & Services Administration. There are currently more than 100,000 people waiting on the national transplant list and a new person is added to the list every 10 minutes.。    AI摘要      国民党籍民代徐巧芯批评台行政机构负责人卓荣泰拒副署“儿少账户条例”是恶意曲解规定。她指此举伤害立法权，强调行政机构应按民意机构三读通过的法律执行。         台当局行政机构负责人卓荣泰不副署台民意机构“三读”通过的“儿少成长及未来账户条例”，国民党籍台民意机构负责人韩国瑜重批，“执政权”再大，都大不过台湾地区现行宪制性规定，两人隔空互杠。国民党籍民代徐巧芯19日受访表示，韩国瑜“雷霆之怒应该发，而且早该发”，且卓荣泰是读了台湾地区现行宪制性规定后，恶意去曲解。         据台媒“中天新闻”报道，徐巧芯指出，卓荣泰的态度一直以来都在摆烂，“在野党”民代在审查总预算或各项“法案”时都是忍无可忍，认为无需再忍。其实也看到台行政机构的态度非常嚣张，使得两边开始对抗。    针对卓荣泰要求韩国瑜“读好台湾地区现行宪制性规定”的说法，徐巧芯反击称，卓荣泰并不能代表“宪法法庭”，在“宪法法庭”尚未做出任何决议前，台行政机构就应该按照台民意机构“三读”通过的“法律”执行。她也说，台民意机构提出的叫做“法律案”而非“预算案”，两者并不相悖。预算编列虽属台行政机构职权，但“法律案”的提出是台民意机构的权力，所以卓荣泰是在刻意曲解法律。

B |     徐巧芯更举例，台行政机构近期在“儿少未来账户”等民生法案上拒绝副署，这个跟政治无关，是跟民生有关的“法案”。且“副署权”的本意是为了限制台湾地区领导人权力扩张，让台行政机构负责人能对赖清德产生制衡，而非用来对抗台民意机构。    徐巧芯续批，卓荣泰不是没有读台湾地区现行宪制性规定，而是很恶意地去曲解、扭曲，用各种方式伤害岛内“立法权”。

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